P2-proline-derived inhibitors of calpain I

Bioorg Med Chem Lett. 1998 Oct 6;8(19):2647-52. doi: 10.1016/s0960-894x(98)00470-3.

Authors

R Tripathy¹, Z Q Gu, D Dunn, S E Senadhi, M A Ator, S Chatterjee

Affiliation

¹ Department of Chemistry, Cephalon, Inc., West Chester, PA 19380-4245, USA.

PMID: 9873596
DOI: 10.1016/s0960-894x(98)00470-3

Abstract

The syntheses and biological activities of a series of calpain I inhibitors, derived from D- and L-Pro, are described.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Calpain / antagonists & inhibitors*
Cysteine Proteinase Inhibitors / chemical synthesis*
Cysteine Proteinase Inhibitors / pharmacology*
Humans
Proline / analogs & derivatives*
Proline / chemistry
Proline / pharmacology
Stereoisomerism
Structure-Activity Relationship

Substances

Cysteine Proteinase Inhibitors
Proline
Calpain